Written by Brian K. Vaughan (Lost, PRIDE OF BAGHDAD, EX MACHINA) and with art by Pia Guerra, this is the saga of Yorick Brown—the only human survivor of a planet-wide plague that instantly kills every mammal possessing a Y chromosome. Accompanied by a mysterious government agent, a brilliant young geneticist and his pet monkey, Ampersand, Yorick travels the world in search of his lost love and the answer to why he'sthe last man on earth.